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2023 Fiscal Year Final Research Report

Study of the relationship over time between oral microbiome and lifestyle diseases with the aim of establishing preventive methods for lifestyle diseases

Research Project

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Project/Area Number 21K10202
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57080:Social dentistry-related
Research InstitutionHirosaki University

Principal Investigator

Kobayashi Wataru  弘前大学, 医学研究科, 教授 (50234860)

Co-Investigator(Kenkyū-buntansha) 福田 はるか  弘前大学, 医学部附属病院, 医員 (60816594)
秋山 なつみ  弘前大学, 医学部附属病院, 医員 (80867375)
Project Period (FY) 2021-04-01 – 2024-03-31
Keywords口腔内細菌 / β多様性解析 / 生活習慣病 / 脂質異常症 / 動脈硬化 / 糖尿病 / 歯周病
Outline of Final Research Achievements

The relationship between the oral microbiota and dyslipidemia, atherosclerosis, and diabetes mellitus as lifestyle diseases was analyzed in a cross-sectional and longitudinal manner. Statistical analysis of the diversity of the bacterial flora showed differences in the flora in all diseases. Differences in the bacterial flora affected the development of dyslipidemia. The results of intergroup comparative analysis and multivariate analysis regarding the search for specific bacteria showed that the genus Megasphaera was associated with the development of dyslipidemia. With regard to atherosclerosis, periodontal bacteria were found to be associated. As for diabetes, the genus Lactobacillus was associated with diabetes. Comparison of the number of periodontal bacteria on the tongue showed a significant association with the presence or absence of periodontal disease, suggesting the importance of controlling periodontal disease as a preventive measure against lifestyle diseases.

Free Research Field

口腔科学

Academic Significance and Societal Importance of the Research Achievements

腸内細菌はいわゆる一つの臓器として様々な疾患と関係し、腸内環境を整えるヨーグルトのようなプロバイオティクスに関する研究が多くなされている。近年、口腔内細菌も腸内細菌と同様に様々に全身疾患と関連していることが報告されている。特に一部の歯周病菌が認知症,動脈硬化に関与するとともに腸内細菌へも影響を及ぼすことが明らかとなっている。本研究成果から特定の細菌だけではなく口腔内細菌叢全体が変化する多様性が生活習慣病の発症に影響を及ぼしていることを縦断研究から明らかとした。
口腔は腸内と違い、直接関与できる部位であることから口腔衛生の向上による生活習慣病予防の可能性があることは社会的意義が大きいと考える。

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Published: 2025-01-30  

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