Is periodontitis a predictor of stroke incidence and prognosis?

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K10210
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57080:Social dentistry-related
• Research Institution: Hiroshima University
• Principal Investigator: Aoki Shiro 広島大学, 病院(医), 講師 (10457236)
• Co-Investigator(Kenkyū-buntansha): 祢津 智久 広島大学, 病院(医), 講師 (10457260) ; 西 裕美 広島大学, 病院(歯), 助教 (70403558)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 歯周病菌 / 脳卒中

Outline of Final Research Achievements

A study was conducted to clarify the relationship between periodontitis and the incidence and prognosis of stroke. Serum periodontal antibody titers were measured in patients with acute stroke, and it was found that the higher the antibody titer against P. gingivalis, the higher the incidence of atrial fibrillation. In addition, the amounts of periodontal bacteria present on the tongue of acute stroke patients were measured by real-time PCR, and it was found that high F. nucleatum levels were independently and strongly associated with cerebral white matter lesions and prognosis 3 months after stroke onset.

Free Research Field

脳卒中

Academic Significance and Societal Importance of the Research Achievements

本研究により、歯周病菌感染が脳卒中の発症や予後に強く関連していることが明らかとなった。特に、F.nucleatum菌の感染が脳梗塞の発症および転帰に強く影響している可能性が示された。本研究により、特異的細菌や口腔環境を標的とした脳卒中発症予防の発展および予後改善に向けた取り組みへの応用が期待できる。