2023 Fiscal Year Final Research Report
Basic study of new periodontal disease prevention method using antibody drug
| Project/Area Number |
21K10269
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57080:Social dentistry-related
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| Research Institution | Osaka Dental University |
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Principal Investigator |
GODA Seiji 大阪歯科大学, 歯学部, 教授 (70351476)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | ケモカイン / RANKL / 抗CX3CL1 / 中和抗体 |
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| Outline of Final Research Achievements |
The academic significance of the research results is that they aimed to develop an antibody drug for chronic periodontitis using neutralizing antibodies, and examined the effectiveness of CX3CL1 neutralizing antibodies on chronic periodontitis. The results showed that alveolar bone resorption caused by P. gingivalis infection was suppressed by administering CX3CL1 neutralizing antibodies, and further suggested that CX3CL1 is strongly involved in the degradation of MyD88 and RANKL expression caused by LPS infection. The social significance of the research results is that they suggest the possibility of neutralizing antibodies as a biological drug as a treatment for chronic periodontitis in the future.
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| Free Research Field |
免疫学・歯周病学・生理学
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| Academic Significance and Societal Importance of the Research Achievements |
研究成果の学術的意義は中和抗体用いて慢性歯周炎の抗体医薬開発を目指して、慢性歯周炎へのCX3CL1中和抗体の有効性について検討した結果P.gingivalis菌感染による歯槽骨吸収は、CX3CL1中和抗体投与により歯槽骨吸収は抑制された．更にLPS感染によるMyD88の分解およびRANKL発現にはCX3CL1刺激が強く関与していることが示唆された点である。研究成果の社会的意義は今後慢性歯周炎の治療薬として中和抗体という生物製剤の可能性が示唆されたことである。
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