2023 Fiscal Year Final Research Report

Prevention of Skeletal Muscle Fibrosis by a Novel Electrical Stimulation Method - Development of an Effective Treatment for Secondary Sarcopenia-

Research Project

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Project/Area Number	21K11172
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 59010:Rehabilitation science-related
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	TOYAMA SHOGO 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (00388183)
Co-Investigator(Kenkyū-buntansha)	中川周士京都府立医科大学, 医学(系)研究科(研究院), 助教 (30643382) 新井祐志京都府立医科大学, 医学(系)研究科(研究院), 准教授 (50347449)
Project Period (FY)	2021-04-01 – 2024-03-31
Keywords	サルコペニア / 治療的電気刺激 / 慢性低酸素 / 遅筋
Outline of Final Research Achievements	In our previous studies, we have elucidated that muscle wasting (equivalent to sarcopenia in humans) in a rat model of inflammatory joint disease exhibits a different pathophysiology from the sarcopenia commonly associated with aging. Additionally, while exercise has traditionally been considered harmful in humans and thus avoided, our findings suggest that it may have beneficial effects in the context of inflammatory joint disease in model rats. This study aimed to explore optimal conditions for maximizing these beneficial effects through hypoxic exercise and the use of electrical stimulation devices. These findings have been presented in English journals and at domestic conferences, generating significant interest and paving the way for future research.
Free Research Field	リハビリテーション医学
Academic Significance and Societal Importance of the Research Achievements	既存のサルコペニア治療、特に2次性サルコペニアの治療における業界の常識は、「栄養を十分に取りつつ、できるだけ強度の高い運動をできるだけ多く行う」であった。これにより、若年者では時間がかかりつつも治療が可能であったが、高齢者では一定程度を超えると治療不可となっていた。一方でわれわれの結果は、人工的な低酸素環境や受動的刺激による代替治療が成立する可能性を示している。本研究で得られた知見は、現状のリハビリテーション医学における超高齢化社会への対応に一石を投じる可能性がある。