Physical exercise program on immune activity in patients with hematological malignancy

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K11176
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Fukushima Medical University
• Principal Investigator: Morishita Shinichiro 福島県立医科大学, 保健科学部, 教授 (60635077)
• Co-Investigator(Kenkyū-buntansha): 椿 淳裕 新潟医療福祉大学, リハビリテーション学部, 教授 (50410262)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 血液がん / 化学療法 / リハビリテーション / 免疫細胞 / 炎症性サイトカイン / 理学療法 / 筋力 / 運動耐容能

Outline of Final Research Achievements

Eighteen haematological cancer patients undergoing chemotherapy were divided into two groups: reduced 6-minute walk group (N=5) and increased 6-minute walk group (N=13) to compare physical function, nutritional status, quality of life, immune cells and inflammatory cytokine results at discharge and one month after discharge The increased 6-minute walk group showed significant increases in physical function, nutritional status and QOL significantly increased at 1 month post-discharge compared to discharge (p<0.05). No significant interactions were found for each of the measures between groups and time periods.
One month after discharge from hospital, haematological cancer patients with increased 6-minute walks tend to have increased quality of life as well as muscle strength and muscle mass. However, immune cells and inflammatory cytokines were not affected during this period.

Free Research Field

リハビリテーション

Academic Significance and Societal Importance of the Research Achievements

化学療法を受けた血液がん患者は退院1か月後は退院時に比べて、身体機能が向上しやすい。特に持久力が向上する患者は筋力や筋肉量や栄養状態、QOLが増大する可能性があり、リハビリテーションや運動療法の重要性を示している。今回、持久力が増大した患者と持久力が低下した患者との間で免疫細胞や炎症性サイトカインにおいて有意差を示さなかった。これらの結果は症例数が少なかったことや、測定時期が短かったことによる影響ではないかと考えられる。