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2023 Fiscal Year Final Research Report

Low muscle mass in critically ill pediatric patients

Research Project

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Project/Area Number 21K11215
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionKyushu University

Principal Investigator

Matsuoka wakato  九州大学, 大学病院, 助教 (70748003)

Co-Investigator(Kenkyū-buntansha) 賀来 典之  九州大学, 大学病院, 助教 (50600540)
赤星 朋比古  九州大学, 医学研究院, 教授 (20336019)
鉄原 健一  地方独立行政法人福岡市立病院機構福岡市立こども病院(臨床研究部), 臨床研究部, 診療科長 (50861522)
Project Period (FY) 2021-04-01 – 2024-03-31
Keywords筋肉量 / サルコペニア / 大腿直筋 / 小児
Outline of Final Research Achievements

Muscle mass (rectus femoris) was measured by ultrasonography in critically ill pediatric patients admitted to the pediatric intensive care unit (PICU) of Kyushu University Hospital for more than 48 hours over a 2-year period beginning in 2021. In addition, myostatin and IL-15, two of the muscle-derived bioactive substances and myokines, were measured. Muscle mass was measured at admission to the PICU, day 3, day 7, day 14, and day 28, and decreased over time in most patients. Similarly, myostatin was found to decrease over time.

Free Research Field

小児集中治療

Academic Significance and Societal Importance of the Research Achievements

重篤小児患者における筋肉量低下は、ICU退室後の身体機能障害に結びつく可能性があるが、その実態は十分には把握されていない。本研究は、PICUに入室した患者の筋肉量低下を明らかとした。また、重篤小児患者でマイオカインを測定した研究は少なく、小児の筋肉量低下におけるマイオカインの意義を検討する一助となる。

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Published: 2025-01-30  

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