Elucidation of arteriosclerosis's onset by using computer model

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K12131
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 62010:Life, health and medical informatics-related
• Research Institution: Okayama University of Science
• Principal Investigator: Yamada Satoshi 岡山理科大学, 情報理工学部, 教授 (20393506)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 動脈硬化 / 炎症アンプ / シミュレーション / IL-6 / NFkB

Outline of Final Research Achievements

The computer model which contains the inflammation amplifier model in the endothelial cells and cellular interactions in the subendothelial space was developed in order to simulate the onset of the atherosclerosis. The model mimicked the foam cell accumulation in the subendothelial space, the LDL-HDL dependency, and the difference between F759 mutant and the wild-type. Based on the sensitivity analysis and the analysis on models with modified parameters, it is considered that the NFkB movement to the nucleus, the binding of NFkB and STAT3, SOCS production, the infiltration of monocyte by VCAM are important for the onset of the atherosclerosis.

Free Research Field

バイオインフォマティクス

Academic Significance and Societal Importance of the Research Achievements

動脈硬化発症モデルとなりうるコンピュータモデルを構築できたので、このモデルを用いて動脈硬化発症メカニズムの解析が可能になり、生物が実験を減らすことができる。また、新規薬物や新規治療法の候補をモデルを使って提案することが可能になる。動脈硬化は心疾患や脳血管障害の原因であるので、動脈硬化の発症メカニズムを解析できるモデルの意義は大きい。