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2022 Fiscal Year Final Research Report

The mechanism of salt taste perception by a novel subpopulation of taste bud cells

Research Project

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Project/Area Number 21K14801
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 38050:Food sciences-related
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

KOZONO Takuma  東京農工大学, 学内共同利用施設等, 特任助教 (20876180)

Project Period (FY) 2021-04-01 – 2023-03-31
KeywordsJaw1 / イノシトール三リン酸受容体 / カルシウムシグナリング / 味蕾細胞
Outline of Final Research Achievements

Of the five basic tastes: sweet, bitter, umami, sour, and salty, the details of the taste bud cell responsible for the salt taste perception and their molecular mechanisms are not yet completely understood. In this study, we demonstrated that the interaction of Jaw1, which is specifically expressed in the subpopulation of taste bud cells, with the type III inositol trisphosphate receptor (ITPR3) enhances the calcium release from the endoplasmic reticulum upon G protein-coupled receptor stimulation. In addition, the calcium assay using taste bud cells isolated from the mouse tongue suggests that Jaw1-positive taste bud cells are one of the cells responsible for salt taste perception. Single-cell transcriptomics of taste bud cells also revealed several genes specifically expressed in Jaw1-positive taste bud cells.

Free Research Field

分子細胞生物学

Academic Significance and Societal Importance of the Research Achievements

本研究において、塩味の感知を担う細胞集団とそのメカニズムの一端を明らかにしたことは、複雑な味覚機能の理解を進める上で学術的貢献度が高く、この理解の更なる深化は塩分の過剰摂取を防ぐための食事方法の提案や味覚障害の治療法の開発等に寄与する可能性があり社会的意義も大きい。また、シングルセルレベルでの網羅的な遺伝子発現解析により得られた知見も元にすると、味蕾細胞集団の分類を従来よりもさらに細分化させた視点も踏まえながら、味覚機能に関する研究を進めることが今後期待される。

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Published: 2024-01-30  

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