2023 Fiscal Year Final Research Report
Fundamental research to establish a new treatment for DIC caused by canine malignancy
| Project/Area Number |
21K14992
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 42020:Veterinary medical science-related
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| Research Institution | Okayama University of Science |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | canine tumor / coagulation / tissue factos / thrombomodulin / statin |
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| Outline of Final Research Achievements |
I investigated the mRNA expression levels of tissue factor (TF) and thrombomodulin (TM) in various canine tissues, including tumor tissues. There were no significant differences in TF or TM expression between benign tumors and epithelial or mesenchymal malignancies. In splenic malignancies, TM expression tended to be lower in tumorous lesions compared to non-tumorous lesions, suggesting that reduced TM expression may contribute to the formation of a hypercoagulable state.
Focusing on statins as agents that can regulate TF and TM expression, I examined their effects on canine hemangiosarcoma cells in vitro. The results demonstrated that statins inhibited cell proliferation, decreased TF expression, and increased TM expression.
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| Free Research Field |
Veterinary oncology
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| Academic Significance and Societal Importance of the Research Achievements |
様々なイヌ腫瘍組織における組織因子 (TF) やトロンボモジュリン (TM) の発現を調査した報告はこれまでないため，イヌ腫瘍におけるTFやTMに関する研究の基礎的知見を提示することができた。
スタチンのTFやTMに関連した抗凝固作用をイヌで調べた報告はこれまでにない。イヌ血管肉腫において抗腫瘍，抗凝固作用を期待した治療薬としてスタチンが応用できる可能性を示せた。
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