2022 Fiscal Year Final Research Report
Development of an environmentally friendly method for creating novel drug-like structures by reducing the oxidation state in highly oxygenated natural products
| Project/Area Number |
21K15224
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Keywords | 触媒反応 / 脱酸素化反応 / バイオマス |
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| Outline of Final Research Achievements |
Catalytic deoxygenation process for sugars have been developed. In this process, the oxidation state of each functional group in the molecule is adjusted intramolecularly before the deoxygenation step, and no external reducing agents are needed.
During the course of the project, novel hypervalent iodine compounds were unexpectedly found.
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| Free Research Field |
有機化学
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| Academic Significance and Societal Importance of the Research Achievements |
天然物は再生可能である上に、多様な生理活性を持っています。しかしながら、天然物そのものを医薬品として用いるには物性的な課題があることが多く、医薬品の多くは石油原料から合成されています。本研究では、天然物を改変し新規の医薬品候補化合物へと導くことを目的とした有機合成化学的手法の開発を行いました。具体的には、糖類の新規脱酸素法の開発に成功しました。本成果は、医薬品分野に限らず再生可能燃料・化成品などへの応用が期待されます。
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