Development of diversification using transition metal catalysts based on the characteristics of oximes

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K15233
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
• Research Institution: Research Foundation Itsuu Laboratory (2022-2023); Showa Pharmaceutical University (2021)
• Principal Investigator: Tanaka Kosaku, III 公益財団法人乙卯研究所, その他部局等, 研究員(移行) (10845639)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: オキシム / パラジウム / カップリング反応 / 銅 / 二トロン

Outline of Final Research Achievements

This research focuses on "Development of Diversification Using Transition Metal Catalysts Based on the Characteristics of Oximes." By leveraging the nucleophilic properties of the oxime carbon resulting from the potential polarity inversion of oximes and the reactivity of transition metals, we attempt to selectively transform the oxime carbon. Ketoximes are highly valuable functional groups seen as ubiquitous structures in synthetic and medicinal chemistry. Additionally, ketoximes are equivalent to ketones, and establishing efficient synthetic methods for ketoximes is also significant in various ways, as it relates to the synthesis of the highly versatile functional group ketones. In the development of this reaction, several byproduct reactions were also observed, and these reactions were examined in detail.

Free Research Field

反応開発

Academic Significance and Societal Importance of the Research Achievements

本研究では、オキシムの極性転換を用いた変換反応を追求し、その過程でオキシムの潜在的な反応性を明らかにしました。オキシムを出発物質とする研究は、薬学や材料化学といった幅広い分野に影響を与える可能性があります。本研究の成果は、新たな合成経路や反応メカニズムの発見につながり、特に新薬の開発や機能性材料の創製に寄与すると期待されます。また、本研究の成果は学術的および社会的意義が大きく、多方面への波及効果が期待されます。