2023 Fiscal Year Final Research Report
Construction and evaluation of a human blood-brain barrier micro-chip derived from human iPS cells that reconstructs the brain microenvironment
| Project/Area Number |
21K15321
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 47060:Clinical pharmacy-related
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 血液脳関門 / トランスポーター / ヒトiPS細胞 / 3次元培養 / MPS / Organ-on-a-chip |
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| Outline of Final Research Achievements |
The purpose of this study is to construct a three-dimensional flow culture system with brain microvascular endothelial-like cells derived from human iPS cells (hiPS-BMECs) as a model for the human blood-brain barrier (BBB). This system using OrganoPlate 3-lane (MIMETAS) reproduces the strong tight-junction and the selective transport function via transporters that are characteristic of the human BBB, and will be beneficial in the development of therapeutics for CNS disorders.
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| Free Research Field |
薬物動態学
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| Academic Significance and Societal Importance of the Research Achievements |
認知症をはじめとする中枢疾患の罹患数が急増している我が国では有効な治療薬の開発が喫緊の課題であり、治療薬の開発を促進するためにヒトBBBの機能を再現し評価可能なシステムの開発が求められている。BBBの機能は微小血管構造や血流等の影響を受けることから、これらの脳内環境を再現する3次元フロー培養システムは中枢疾患の治療薬開発の一助となることが期待されている。
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