Mechanism of peritumor micro-environment for PCNSL using model mice

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K15420
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49030:Experimental pathology-related
• Research Institution: Tokai University
• Principal Investigator: Nakayama Shunya 東海大学, 医学部, 奨励研究員 (70884196)
• Project Period (FY): 2021-04-01 – 2023-03-31
• Keywords: 中枢神経原発性悪性リンパ腫 / PDXマウス

Outline of Final Research Achievements

Although 90% of primary malignant lymphomas of the central nervous system (PCNSL) are classified as diffuse large B-cell lymphomas that are expected to respond to antitumor drugs, many antitumor drugs cannot cross the blood-brain barrier because the tumor is confined to the cranium. Therefore, it is known to have a worse prognosis than the more common diffuse large B-cell lymphoma. In addition, because surgical resection is not indicated for this highly invasive tumor, research samples are scarce, and basic research in Japan and abroad has been stagnant.
In this study, we focused on the microenvironment surrounding PCNSLs and investigated their interaction by in silico analysis using PDX mice and CASTIN.

Free Research Field

実験動物学

Academic Significance and Societal Importance of the Research Achievements

PCNSLは非常に稀な疾患である一方、標準治療は患者への負担が大きいものが多い。
本研究ではPCNSLの病態を明らかとし、腫瘍と周囲組織とのインタラクションを明らかとすることで治療標的を探索するものである。
従来の方法では見つけられない因子をPDXマウスとCASTINを始めとしたin silico解析を用いることで新たな中心的因子を明らかとすることを目指した。得られた結果は今後のPCNSL治療ならびにDLBCL治療の基盤となると考えられる。