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2022 Fiscal Year Final Research Report

Identifying antibiotics using the conserved allostery from respiratory complex

Research Project

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Project/Area Number 21K15443
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 49050:Bacteriology-related
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Nishida Yuya  国立研究開発法人国立循環器病研究センター, 研究所, 室長 (10793440)

Project Period (FY) 2021-04-01 – 2023-03-31
Keywordsシトクロムc酸化酵素 / 呼吸鎖 / 薬剤耐性菌 / 抗菌薬 / アロステリック阻害剤 / クライオ電子顕微鏡 / X線結晶構造解析
Outline of Final Research Achievements

In recent years, there has been a rapid emergence of drug-resistant pathogens. As a countermeasure, the development of antibiotics with new mechanisms is strongly demanded. However, the issue of adverse effects on humans has become a concern. In this study, we developed a rational method to identify pathogen-specific inhibitors that target the respiratory chain complex, which is conserved in humans. Finally, we demonstrated the antimicrobial effect against a clinically isolated super-resistant gonococci.

Free Research Field

タンパク質機能構造解析

Academic Significance and Societal Importance of the Research Achievements

本研究では、病原菌では創薬標的として期待が高い呼吸鎖酵素を標的としており、その成果は、学術的のみならず、医療や産業への展開が期待できる。さらに、髄膜炎菌/淋菌酵素でも特異的な阻害剤を発見し、これが薬剤耐性淋菌に対して殺菌作用を持つことを示したことは、申請者の仮説を実証する内容である。以上の結果を論文としてまとめ発表した (Nishida et al. Nature commun., 2022)。

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Published: 2024-01-30  

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