The molecular and functional role of chronic kidney disease in bladder cancer

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K15506
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Hiroshima University
• Principal Investigator: Kobatake Kohei 広島大学, 病院(医), 助教 (10749998)
• Project Period (FY): 2021-04-01 – 2023-03-31
• Keywords: 膀胱癌 / 慢性腎臓病

Outline of Final Research Achievements

We previously evaluated the renal function before transurethral bladder tumor resection in patients with non-muscle-invasive bladder cancer, and we demonstrated a significantly higher recurrence rate after surgery in patients with preexisting chronic kidney disease (CKD), particularly those with an eGFR (estimated glomerular filtration rate) < 45. CKD is currently recognized as a common disease and is expected to continue increasing in prevalence. In this study, our objective was to elucidate the molecular mechanisms underlying this association. As a result, we observed an upregulation of genes known to be involved in the development and progression of various tumors, including bladder cancer. The findings from this study provide a foundation for the development of novel therapeutic approaches for bladder cancer.

Free Research Field

膀胱癌

Academic Significance and Societal Importance of the Research Achievements

膀胱癌のうち、筋層非浸潤性膀胱癌は進展リスクこそ高くないものの、全ての固形癌の中で最も局所再発を起こしやすい癌として知られる。また慢性腎臓病は現在罹患率が上昇傾向であり、今後も患者数の増加が見込まれている。筋層非浸潤性膀胱癌の治療コストは長期にわたる経過観察と治療により増加し、また患者ＱＯＬは著しく低下する。少しでも再発率を低下させる事は喫緊の課題と得る。我々の研究成果を基に新規阻害剤を開発することで、これらの問題を解決しうるものと考えられる。