Regulatory mechanisms of cell-cell interactions mediated by ANGPTL2 in the tumor microenvironment

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K15508
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Kumamoto University
• Principal Investigator: Horiguchi Haruki 熊本大学, 大学院生命科学研究部(医), 特任助教 (70755454)
• Project Period (FY): 2021-04-01 – 2023-03-31
• Keywords: がん免疫

Outline of Final Research Achievements

The diversity of the cancer microenvironment is the greatest obstacle to the development of cancer therapies, and a complete understanding of the cancer microenvironment is essential for the development of innovative cancer therapies. Recently, it has been reported that ANGPTL2 has dual roles of cancer promotion and suppression, depending on the expressing and target cells. In this study, it was suggested that cancer cell-derived ANGPTL2 and fibroblast-derived ANGPTGL2 have different glycosylation, and that this difference determines the cancer-promoting and cancer-suppressing effects of ANGPTL2. In addition, it was suggested that the difference in carcinogenic context determined the priority of the cancer-promoting effect of cancer cell-derived ANGPTL2 and the cancer-suppressing effect of stroma-derived ANGPTL2.

Free Research Field

腫瘍生物学

Academic Significance and Societal Importance of the Research Achievements

これらの知見は、これまで明らかにされてこなかったがん微小環境の細胞間ネットワーク構築を担う分子群の理解に新たな視点を与えることが期待でき、一人ひとりの遺伝子発現、細胞構成に合わせたがん治療戦略の確立への応用が期待される。