Establishment and clinical application of intratumoral heterogeneity analysis in brain tumors

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K15521
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Tokyo Metropolitan Hospital Organization Tokyo Metropolitan Komagome Hospital
• Principal Investigator: Ryohei Otani 地方独立行政法人東京都立病院機構東京都立駒込病院(臨床研究室), 脳神経外科, 医長 (30786968)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 脳腫瘍 / 腫瘍内多様性

Outline of Final Research Achievements

The purpose of this study was to establish a method to analyze intratumoral heterogeneity in general clinical practice, which is currently performed only at the research level, and to clarify its clinical significance. We analyzed intratumoral heterogeneity by performing a comprehensive genomic variant analysis of spatially separated regions in16 brain tumor cases. A phylogenetic tree of intratumoral clonal evolution was generated from the somatic mutation data obtained for each site, and evolution was predicted to spread from the ventricular side to the surface of the brain. The results also suggest that the degree of intratumoral heterogeneity may correlate with the time to recurrence. The results of this study have clinical implications for the analysis of intratumoral heterogeneity in clinical practice and are expected to influence future treatment strategies for brain tumors.

Free Research Field

脳腫瘍

Academic Significance and Societal Importance of the Research Achievements

本研究の結果は、日常臨床における腫瘍内多様性の解析の臨床的意義につながるものであり、今後の脳腫瘍の治療戦略に大きな影響を与え、脳腫瘍患者の予後改善への貢献が期待される。