Effects of 1,5-AG, as one of the glycemic control indicators, on age-related changes in energy metabolism

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K15653
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: Dokkyo Medical University
• Principal Investigator: Morita Asuka 獨協医科大学, 医学部, 助教 (30780902)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 1,5-アンヒドログルシトール

Outline of Final Research Achievements

A sugar alcohol called 1,5-anhydro-D-glucitol (1,5-AG) exists in the human body. In recent years, it has been reported that the blood 1,5-AG concentration decreases with aging. However, the physiological role of 1,5-AG and the effects of its decrease are still largely unknown. In this study, our aim was to clarify two things: (1) the physiological role of 1,5-AG in energy metabolism and (2) the changes in 1,5-AG metabolism that occur with aging. Adult and aged mice were treated with 1,5-AG, respectively, and the changes in expression levels of genes involved in energy metabolism were assessed. Significant changes in gene expression were observed in the 1,5-AG-treated mice compared to the control group, suggesting the involvement of 1,5-AG in energy metabolism.

Free Research Field

薬理学

Academic Significance and Societal Importance of the Research Achievements

1,5-アンヒドログルシトール（1,5-AG）は様々な食品に含まれており、日々の食事から摂取している。加齢に伴い血中1,5-AG濃度が減少することが報告されているが、1,5-AG減少に伴う生体への影響は未だ不明である。本研究では、1,5-AGのエネルギー代謝における役割の解明を目指し、1,5-AGがエネルギー代謝に関与している可能性を見出した。さらに、高齢マウスに対する1,5-AGの補充が動物個体レベルの糖代謝に不利な影響を与えないことが示されたことから、加齢による血中1,5-AGの減少を1,5-AGの補充により是正することが生体に有利な効果を示す可能性が示された。