Elucidation of physical factors and establishment of correction technology for dual-isotope simultaneous acquisition using cardiac semiconductor SPECT

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K15761
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kanazawa University
• Principal Investigator: Shibutani Takayuki 金沢大学, 保健学系, 助教 (80762509)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 複数分子同時収集 / SPECT / 心臓核医学 / クロストーク

Outline of Final Research Achievements

In the multiple-isotope simultaneous acquisition technique of the cardiac semiconductor SPECT system, image quality deterioration in myocardial position dependence, quantitative accuracy deterioration due to crosstalk, and image quality deterioration due to scattered ray components from I-123 energy of 529 keV occurred, and their effects were dependent on the myocardial accumulation ratio of the multiple-isotope simultaneous acquisition. To solve these problems, we constructed a new physical phantom and dynamic system, clarified the optimal myocardial accumulation ratio, and established a correction technique to improve image quality.

Free Research Field

核医学技術

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は，同一時相で複数分子情報を高精度に定量評価することができ，心疾患の病態解明，治療戦略および治療効果判定の精度向上に役立つだけでなく，全身用装置にもこの技術を展開でき，近い将来に開発される123I標識トレーサにも応用できる。さらに，今後，循環器学のみならず，脳科学，腫瘍学などあらゆる分野に展開でき，波及効果が期待できるため意義が高い。