Analytical study on blood flow factors for reduction of vascular stenosis of AV fistula of hemodialysis patients

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K15838
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Tohoku University
• Principal Investigator: Kinoshita Tomo 東北大学, 大学病院, 特任助手 (00836538)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 透析シャント / 狭窄 / wall shear stress

Outline of Final Research Achievements

In this study, we identified the range of anastomotic angles on AV fistula that can reduce the WSS value by calculating the WSS value, which is a factor in AV fistula stenosis, using fluid simulation with patient data, and proposed an ideal AV fistula shape (anastomotic angle) that can actually be realized in vivo and its procedural flow. Since the proposed AV fistula shape cannot be maintained spontaneously, the cover device proposed by us was applied in vivo, and it was found that the assumed ideal shape could be maintained, and fluid simulation showed that the shape reduced WSS more than before. This demonstrates the fundamental efficacy of our device in improving AV fistula shape and maintaining the shape.

Free Research Field

放射線診断

Academic Significance and Societal Importance of the Research Achievements

本製品の学術的意義及び社会的意義は、これまでなかった「根本的な狭窄の抑制」を実現し、AV シャント患者の狭窄の発症および狭窄治療を最大46%低減することである。また、患者は狭窄が減るだけでなく、従来の狭窄治療(バルーンカテーテルによる血管拡張)による再狭窄リスクも低減可能である。従ってAV シャントを有する血液透析患者のQOL 向上が期待される。また、透析管理を行う医療従事者(透析専門医、透析を実施する看護師および臨床工学技士、狭窄治療を実施する放射線診断医)に発生している狭窄リスク管理・治療対応などの業務負担を軽減可能となる。