novel biomarkers focusing on platelet aggregation in hepatic sinusoidal obstructive syndrome

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K16460
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Kanazawa Medical University
• Principal Investigator: MIYATA Takashi 金沢医科大学, 医学部, 講師 (60765949)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 肝類洞閉塞症候群 / 血小板 / 薬剤性肝障害 / 肝臓外科学

Outline of Final Research Achievements

Mice model of SOS groups and effected cilostazol were made. Platelet counts significantly decreased in the Mice model of SOS groups compared with those in the control group, and the results of serum AST, ALT, and hyaluronic acid in SOS groups were significantly higher than those in the control group. These changes were significantly suppressed in the model effected by cilostazol.
Histopathological findings showed sinusoidal dilatation and endothelial damage of the central vein in the SOS group, and in the model effected by cilostazol group changes were attenuated. PAI-1 expression was similarly suppressed by cilostazol.

Free Research Field

肝臓学

Academic Significance and Societal Importance of the Research Achievements

本研究は、マウスにおける薬剤性SOS肝障害モデルを用いて、SOSの程度とPAI-1値などの相関を調べることで、SOSのバイオマーカーとしての意義を明らかにすることを目的とした。現在、SOSの早期診断、重症度判定、予防・治療の方法は確立されておらず、本研究は、肝臓外科手術の重篤な合併症の一つであるSOSの病態解明につながると共に、SOSの早期診断や治療法の確立に寄与すると確信する。