Hyperglycemia Induced by Vasculitis

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K16570
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Gifu University
• Principal Investigator: Yoshida Shozo 岐阜大学, 大学院医学系研究科, 特任教授 (40339346)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 糖尿病 / 急性炎症

Outline of Final Research Achievements

Progressive insulin deficiency has become a possibility in patients with type 2 diabetes as the duration of the disease increases. When the size of pancreatic islets of Langerhans was measured, hyperplasia of islets of Langerhans was observed in type 2 diabetes model (db/db) mice with significantly increased size of islets of Langerhans in the pancreas at both 6 and 9 weeks of age compared to WT mice. In addition, the microporous structure of the vascular endothelium in the pancreatic islets of Langerhans showed enlarged pores and edema formation around the vessels and cells in diabetic mice compared to healthy mice, suggesting the existence of microcirculatory disturbance as a cause of insulin secretory insufficiency. Induction of vasculitis exacerbated vascular endothelial damage.

Free Research Field

救急・集中治療

Academic Significance and Societal Importance of the Research Achievements

近年、敗血症の病態解明や治療法の進歩は認められるものの、膵臓血管内皮の構造や血管内皮障害に言及した報告は未だ少ない。さらに血管内皮GCXは細胞の恒常性維持に重要な役割を果たしており、その機能維持・回復は新しい治療の開発のターゲットとして注目されている。しかし疾患の病因・病態からのアプローチは遅れているのが現状である。そのため本研究のようなアプローチは学術的意義が高いと考えられる。