Identification of mechanisms leading to chronic inflammation in the arterial wall responsible for the progression of intracranial aneurysm

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K16622
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Jikei University School of Medicine (2023); National Cardiovascular Center Research Institute (2021-2022)
• Principal Investigator: Kayahara Tomomichi 東京慈恵会医科大学, 医学部, 講師 (10895478)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 脳動脈瘤 / 慢性炎症 / 内弾性板 / マクロファージ

Outline of Final Research Achievements

Recent studies have revealed that macrophage-dependent chronic inflammation in arterial walls regulates the progression of intracranial aneurysm. In the present study, I examined the mechanisms triggering the macrophage invasion into the arterial wall. As a result, I identified initial morphological changes of internal elastic lamina and surrounding cells which may lead to the disruption of internal elastic lamina. Also, I'm trying to clarify how the disruption of internal elastic lamina could be induced.

Free Research Field

脳血管障害

Academic Significance and Societal Importance of the Research Achievements

本研究では、内弾性板断裂につながると考えられる初期の形態学的変化を同定した。内弾性板断裂機構の解明は、慢性炎症に関連する個々の分子にアプローチするのではなく、脳動脈瘤病変部における慢性炎症反応の場の形成自体を阻害するという革新的な戦略の開発につながることが期待される。また、慢性炎症局面の形成は脳動脈瘤のみならず多くの疾患に共通の病態制御基盤であり、本研究の進展は炎症性疾患全般の病態形成機構の理解の一助となり得るものと考える。