2022 Fiscal Year Final Research Report
Exploration of the factors that are released from degenerated cartilage by loading and could cause synovial pathology in osteoarthritis.
| Project/Area Number |
21K16722
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56020:Orthopedics-related
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| Research Institution | Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital |
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Principal Investigator |
Tsuno Hirotaka 独立行政法人国立病院機構(相模原病院臨床研究センター), リウマチ性疾患研究室, 医師 (90792135)
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Keywords | 変形性関節症 / 軟骨 / 膝関節 |
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| Outline of Final Research Achievements |
Synovial changes now have been known to play a central role in osteoarthritis (OA). Although the synovial changes are probably induced by proteins released from OA cartilage, few studies have conducted to identify such proteins. This study was performed to identify the released proteins.OA cartilages were obtained from OA knees at preserved areas and degenerated areas, while control cartilages were collected from non-arthritic knees. Released proteins were obtained from these cartilages by repeatedly applying compressive loading, simulating loading on cartilage in vivo. The released proteins were analyzed by antibody array analyses, a quantitative proteomic analysis, and Luminex assays.
The results of these analyses revealed that several alarmins, complement proteins, and angiogenic proteins are indeed released from OA cartilages, particularly from those obtained from the degenerated areas. This finding may be worth noting for understanding the pathology of OA.
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| Free Research Field |
関節リウマチ、変形性関節症
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| Academic Significance and Societal Importance of the Research Achievements |
変形性関節症は社会の高齢化とともに患者数が増加している疾患であるが、その病態には不明な点が多く、疾患の発症や進行を抑止できる治療法は見当たらない。この疾患では滑膜病変も病態において中心的な役割を果たすことが明らかになった。本研究では滑膜病変の成立に関与するOA軟骨から遊離する因子を初めて直接的な方法で解析した。この知見は滑膜病変の成因を解明する上で極めて重要と考えられ、本研究の成果は滑膜病変を含めたOAの病態解明、およびそれを通したOAの治療法、進行抑止法の確立に直接的に役立つものと思われる。
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