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2023 Fiscal Year Final Research Report

Elucidation of the mechanism of occurrence and progression of ovarian dedifferentiated cancer using organoid culture

Research Project

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Project/Area Number 21K16793
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56040:Obstetrics and gynecology-related
Research InstitutionNagoya City University (2023)
Shimane University (2021-2022)

Principal Investigator

Ishibashi Tomoka  名古屋市立大学, 医薬学総合研究院(医学), 助教 (40643648)

Project Period (FY) 2021-04-01 – 2024-03-31
Keywordsオルガノイド / 卵巣脱分化癌
Outline of Final Research Achievements

Ovarian dedifferentiated cancer is a disease with aggressive and very poor prognosis. Regarding uterine dedifferentiated endometrioid cancer, we reported that the combination of immune checkpoint inhibitors in addition to conventional chemotherapy may have a therapeutic effect (Ono R, Ishibashi T et al., Int J Mol Sci. 2019).
In recent years, 3D cell culture has attracted attention, and we have succeeded in creating spheroid derived from normal endometrial glands and single glands (Sato S, Ishibashi T et al., Cancer Sci. 2023). However, ovarian dedifferentiated cancer is rare, and the next goal is to create an organoid model and research it in detail.

Free Research Field

婦人科がん

Academic Significance and Societal Importance of the Research Achievements

卵巣脱分化癌に関しては症例報告が散見されるのみで、網羅的遺伝子解析やオルガノイドに成功したという報告はない。子宮脱分化型類内膜癌での免疫チェックポイント阻害薬の効果について報告しており、婦人科がんにおける脱分化癌の研究に関しては、本邦では当研究室がリードしている。
また近年in vivo の生理学的環境により近い3次元細胞培養が注目を集めている。3次元細胞培養下での発現プロファイルは2次元培養環境の場合と比較して、生理学的な重要性が高いと考えられている。オルガノイドモデルを用いた卵巣脱分化癌発生機構の検討は世界でも報告されておらず、今後の卵巣脱分化癌の研究基盤とな

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Published: 2025-01-30  

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