The relationship between pregnancy outcome and metagenomic analysis in microbiome in oral placenta of pregnant women

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K16824
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Osaka Medical and Pharmaceutical University
• Principal Investigator: Sano Takumi 大阪医科薬科大学, 医学部, 非常勤医師 (30817185)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: metagenomic analysis / oral bacterial flora / placenta / pregnancy / 口腔内細菌叢 / 胎盤 / 妊娠

Outline of Final Research Achievements

The evaluation of oral microbiome from mothers and infants showed that the alpha diversity of the oral flora was lower in newborns than in mothers, and the alpha diversity of the maternal flora did not change before or after delivery. There were also large differences in diversity between mothers and newborns. The composition of the bacterial flora was dominated by Firmicutes in the newborns at the phylum level and Streptococcus in the newborns at the genus level, with fewer species in the newborns than in the mothers, and variation was also observed among the newborns. The relationship between the oral microbiome of mothers and perinatal complications was examined for preterm delivery, hypertensive disorder of pregnancy, and gestational diabetes mellitus, but no significant differences were found in the diversity of the oral microbiome compared to the control group.

Free Research Field

産婦人科

Academic Significance and Societal Importance of the Research Achievements

本邦において母児の口腔細菌叢及び生活習慣、妊娠中の健康状態と、妊娠の転帰や乳幼児の口腔細菌叢形成及び成長・発達・健康状態との関連を検討することができた。