Elucidation of the effects of Pg infection on the pathogenesis of diabetes through intestinal dysbiosis

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K16968
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Hiroshima University
• Principal Investigator: Akutagawa Keiichi 広島大学, 医系科学研究科(歯), 専門研究員 (40826369)
• Project Period (FY): 2021-04-01 – 2023-03-31
• Keywords: 歯周炎 / 糖尿病 / う蝕 / 脳出血

Outline of Final Research Achievements

In this research project, we focus on periodontal pathogen P. gingivalis infection and caries-causing bacteria S. mutans dental pulp infection. We elucidated the mechanism using an animal model. P. gingivalis-infected diabetic mice had thickened Peyer's patches and altered gut microbiota compared with diabetic mice. In addition, in a rat model infected with S. mutans, expansion of cerebral hemorrhage was observed due to strong adhesion of bacteria to vascular endothelial cells via extracellular matrix type I and type IV collagen. Elucidation of these mechanisms is expected to lead to the importance of oral treatment and the development of new treatment methods.

Free Research Field

歯周治療学

Academic Significance and Societal Importance of the Research Achievements

本研究課題の成果から、歯周病やう蝕と行った口腔感染症が足がかりとなり、歯周組織から血行性に、または消化管を通して腸内細菌叢へ影響を与えることが明らかとなった。これら局所の変化が全身へ波及（全身疾患の発症、増悪）することも示唆されたことから、今後歯科受診、歯科治療の重要性を国民に周知するための根拠となる結果である。