Development of Innovative Implant Therapy by Synergistic Effects of Immediate Placement and PTH Formulation on Bone Mass and Quality

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K17023
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57040:Regenerative dentistry and dental engineering-related
• Research Institution: Nagasaki University
• Principal Investigator: Uto Yusuke 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (10816680)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: インプラント

Outline of Final Research Achievements

An experimental model of immediate placement of implants in the maxillary bone of rats was developed in which implants were placed at the same time as tooth extraction. The combination of implant placement and localized intraoral administration of PTH accelerated peri-implant bone healing and increased both bone quality and volume. It was also found that post-implantation surgery denatures collagen fibers in the surrounding bone, which remain in the bone for a long period of time. This is thought to affect the mechanical function of the peri-implant bone.

Free Research Field

口腔インプラント学

Academic Significance and Societal Importance of the Research Achievements

臨床ではすでに実施されている抜歯即時インプラント埋入術に対し基礎科学的な裏付けを行う実験モデルをラットにおいて確立した．更にPTH製剤を利用してインプラント治療の欠点の一つである治療期間の長さを短縮する方法を開発したことに社会的意義がある．またPTH製剤の併用で骨量と骨質を改善できることを明らかにし，未だ不明な点の多いインプラント周囲骨における分子生物学的動態を解析したことに学術的意義がある．