The effect of mastication on glucometabolism via vagus nerve in mice

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K17046
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: Kan Yuki 北海道医療大学, 歯学部, 助教 (20803620)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 咀嚼 / アディポネクチン / レプチン

Outline of Final Research Achievements

This study aims to investigate the secretory mechanism mediated by vagus nerve through mastication using c57BL/6J mice.1. The effect of mastication on glucometabolism via vagus nerve in mice. 2. The effect of mastication on glucometabolism via vagus nerve in diabetic model mice were measured. We found significant differences in neuropeptide Y concentration, PEPCK concentration, and pancreatic beta cell area in healthy mice, but no significant differences in leptin concentration. In diabetic model mice, significant differences were observed in leptin concentration, but not in adiponectin concentration, neuropeptide Y concentration, and pancreatic beta cell area.

Free Research Field

歯科補綴学

Academic Significance and Societal Importance of the Research Achievements

本研究は咀嚼による迷走神経を介した分泌メカニズムの検討を行うことを目的として、その結果健常マウスにおいて咀嚼がアディポネクチンに影響を与えたこと、糖尿病モデルマウスにおいて咀嚼がレプチンに影響を与えたことを明らかとした。これらは咀嚼が糖代謝系に与える影響の一因であると考えられる。本研究の成果は糖尿病に対する咀嚼の効果の検証である。