Relationships between maternal serum fatty acids levels during mid pregnancy and cardio ankle vascular index in the offsprings at 8 years of age

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K17290
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Nagoya City University
• Principal Investigator: KANEKO Kayo 名古屋市立大学, 医薬学総合研究院(医学), 講師 (30771547)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 出生コホート / 血中脂肪酸 / DOHaD / CAVI

Outline of Final Research Achievements

This study examined the relationships between maternal serum fatty acid levels during mid-pregnancy and offspring’s cardio-ankle vascular index (CAVI) at 7-8 years as the Adjunct Study of Japan Environment and Children’s Study in Aichi. We described the median and standard deviation of CAVI in Japanese children at 7-8 of age by different sex (n=152). The results had shown no significant relationship between maternal serum fatty acid levels during mid-pregnancy and offspring’s CAVI at 7-8 years (n=51). Since no previous similar large-scale cohort study has investigated the relationships of maternal serum fatty acid levels with offspring’s CAVI, the present findings must be carefully verified in further studies.

Free Research Field

疫学、母子保健

Academic Significance and Societal Importance of the Research Achievements

わが国の動脈硬化性疾患の有病率は高く、その予防は重要な公衆衛生課題である。母体血中脂肪酸は、胎児の心血管・神経系発達に不可欠であり、その過不足は出生以降の動脈硬化の進行に関与するといわれている。しかし、母体血中脂肪酸と児の動脈硬化の程度の関連を調べた先行研究は皆無である。本研究結果では、母体血中脂肪酸と8歳時点の子どものCAVI値の関連はみられなかったが、児の成長に伴い関連が認められるようになるか、今後の研究で検討するうえでの基礎情報が示された。また、今回示された8歳時点の子ども152名(男児76名、女児76名)のCAVI平均値は、日本人小児における参考情報となり得るかもしれない。