2023 Fiscal Year Final Research Report
Implications of vitamin C on epigenetic regulation of epidermal keratinization and its aging changes
| Project/Area Number |
21K17697
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
Sato Ayami 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (30897476)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | ビタミンC / 表皮角化 / エピジェネティクス |
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| Outline of Final Research Achievements |
We comprehensively analyzed gene expression changes induced by vitamin C in neonatal rat epidermal keratinocytes under Tet knockdown. We found significant differences in mRNA expression of genes involved in cornified envelope (CE) formation, which is important for skin barrier function. This study suggests that vitamin C may be involved in CE formation through epigenetics.
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| Free Research Field |
食品機能学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は，皮膚疾患の予防・治療や肌の老化防止に向けたビタミンCの表皮への新たな作用機構を明らかにした．また，将来的に表皮角化エピジェネティクスの理解を基にした皮膚疾患の診断や表皮再生医療の進展などの応用も期待できる．
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