Comprehensive multi-omics analysis for biological aging markers according to frailty model

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K17699
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Waseda University (2022); National Institutes of Biomedical Innovation, Health and Nutrition (2021)
• Principal Investigator: Watanabe Daiki 早稲田大学, スポーツ科学学術院, 助教 (90894501)
• Project Period (FY): 2021-04-01 – 2023-03-31
• Keywords: フレイル / 疫学 / バイオマーカー

Outline of Final Research Achievements

Based on the data of middle-aged and older people, we matched age and gender based on a phenotype model for evaluating frailty and divided them into four groups according to their reserve ability: “fit,” “well,” “pre-frailty,” and “frailty.” classified. This makes it possible to search for biomarkers related to physical reserve ability that are not simply chronological age differences. Biomarkers were evaluated using blood samples. Proteomics detected 2059 proteins, with 44 proteins trending associated with degrees of frailty. On the other hand, in metabolomics, 192 types of metabolites were detected by target analysis, and about 50 known and unknown molecules showed a tendency relationship according to the degree of frailty.

Free Research Field

疫学

Academic Significance and Societal Importance of the Research Achievements

世界中の多くの研究でフレイルの有無が高齢者の健康や寿命に影響を及ぼすことが示されたことに伴い、我が国では2020年4月より75歳以上の後期高齢者を対象に、フレイルの発症予防・重症化予防に着目した健診が開始された。従って、我々のデータは年齢に依存しない生物学的老化との関連要因を明らかにし、フレイルの早期発見の有用な知見を得るであろう。