Construction of a foundation for a biomarker detection system using metal-organic frameworks

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K18092
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 90130:Medical systems-related
• Research Institution: Tokyo Metropolitan Industrial Technology Research Institute
• Principal Investigator: GESSEI Tomoko 地方独立行政法人東京都立産業技術研究センター, 研究開発本部機能化学材料技術部バイオ技術グループ, 主任研究員 (80520220)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 金属有機構造体 / バイオセンサ

Outline of Final Research Achievements

In order to coped with the recent super-aging society and new lifestyles due to the epidemic of novel coronavirus infection, we are required to realize disease prevention and disease condition prediction through health management using sensor technology. In this study, we focused on metal-organic frameworks with high adsorption performance and molecular sieving properties to develop a biosensor with high selectivity. The developed biosensor can be applied to various biomarkers by changing the target substance, which will lead to the realization of a healthy and long-lived society using medical big data and AI/IoT technology.

Free Research Field

人間医工学

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は、金属有機構造体の吸着性能や分子ふるい特性に着目し、バイオセンサにおける金属有機構造体の新しい用途開拓に繋げた点である。本研究で得られた成果は、センサを用いた疾患予防や病態予測への活用が期待でき、社会的意義を有する。