2023 Fiscal Year Final Research Report
Mechanism of Cardiac Regeneration and Developmental Heterochrony
| Project/Area Number |
21K18273
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| Research Category |
Grant-in-Aid for Challenging Research (Pioneering)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 53:Organ-based internal medicine and related fields
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Kimura Wataru 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー (60452182)
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| Co-Investigator(Kenkyū-buntansha) |
清成 寛 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー (40721048)
魚崎 英毅 自治医科大学, 医学部, 准教授 (90740803)
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| Project Period (FY) |
2021-07-09 – 2024-03-31
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| Keywords | 心筋梗塞 / 心筋再生 / 心筋細胞 / AMPK / オポッサム |
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| Outline of Final Research Achievements |
Early neonatal mammals can regenerate the myocardium through the proliferation of cardiomyocytes for only a short period of time after birth. We have shown that neonatal opossum continues cardiomyocyte proliferation for at least 2 weeks after birth. In addition, the opossum heart exhibited regenerative capacity in this period. We performed RNA sequencing and subsequent immunohistochemical, pharmacological and genetic analyses and demonstrated that the AMPK signaling is an evolutionary conserved signaling pathway that regulates cardiomyocyte cell cycle arrest in the postnatal mammalian heart.
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| Free Research Field |
再生生物学
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| Academic Significance and Societal Importance of the Research Achievements |
われわれは出生後に心筋を再生する能力が失われる時期が異なる２種類の哺乳類動物，すなわちマウスとオポッサムとを比較することにより，これまでに明らかにされることがなかった進化的に保存されたシグナル伝達経路が心筋を再生する能力を制御していることを明らかにした．このシグナル伝達経路は新たな心疾患治療法のための標的になりうると考えられる．
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