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2023 Fiscal Year Final Research Report

Development of a cell sheet for odorant detection using insect olfactory receptor-expressing sensor cells

Research Project

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Project/Area Number 21K19107
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 39:Agricultural and environmental biology and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Kanzaki Ryohei  東京大学, 先端科学技術研究センター, 特任研究員 (40221907)

Project Period (FY) 2021-07-09 – 2023-03-31
Keywords匂いバイオセンサ / 細胞シート / 昆虫 / 嗅覚受容体
Outline of Final Research Achievements

To achieve a simple technology for testing gas-phase odorants using insect olfactory receptor-expressing sensor cells, we attempted to develop odorant sensing cell sheets that show fluorescent response to target odorants. We established a method to construct cell sheets by immobilizing sensor cells onto a glass substrate. We demonstrated that the constructed cell sheets showed fluorescent responses to target odorants in the gas phase by measuring them with a compact fluorometer. Thus, we succeeded in developing odorant sensing cell sheets using sensor cells.

Free Research Field

神経行動学

Academic Significance and Societal Importance of the Research Achievements

昆虫の嗅覚受容体を発現させた「センサ細胞」は対象臭成分を検出できる一方、その実用化のためにはセンサ細胞の応答をより簡便に計測する技術の確立が課題であった。本研究により、センサ細胞を活用した匂いセンシングシートの開発技術を確立し、気体を提示するだけで簡便に対象臭を検出できることを実証した。これにより、センサ細胞を活用した対象臭の簡易検査が可能となり、センサ細胞の実用化への一つの道筋ができたことは学術的・社会的に意義がある。

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Published: 2025-01-30  

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