2022 Fiscal Year Final Research Report
Exploration of environmental adaptation mechanism via increased diversity of epigenetic mutations
Project/Area Number |
21K19199
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Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
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Research Institution | Hokkaido University |
Principal Investigator |
Murakami Yota 北海道大学, 理学研究院, 教授 (20260622)
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Project Period (FY) |
2021-07-09 – 2023-03-31
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Keywords | エピジェネティクス / 環境適応 |
Outline of Final Research Achievements |
Recent analyzes using fission yeast revealed diversity in the distribution of ectopic heterochromatin (EHC), and we hypothesized that EHC-mediated gene suppression (epigenetic mutation) contributes to environmental adaptation. and clarified the following two points. 1) We showed that the diversity of EHC distribution increased under stressful conditions. 2) Artificially increased EHC diversity increased the probability of emergence of strains exhibiting drug resistance and auxotrophy, indicating that these were phenotypic changes derived from EHC. The above results indicate that EHC diversity can contribute to environmental adaptation.
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Free Research Field |
分子生物学
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Academic Significance and Societal Importance of the Research Achievements |
環境適応は基本的に突然変異と自然選択によりおこると考えられているが、本研究によりエピジェネティックな変化も環境適応に寄与する事を示すことができた。エピジェネティックは即時的な環境変化への応答と遺伝的な適応の間の中期的時間帯できのうするものと考えられ、生物の適応戦略を考える上で興味深い。今後、このエピジェネティックな環境適応が遺伝的な環境適応に影響を与える可能性を検討することで、適応進化に新しい概念を導入できる可能性がある。
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