Identification of gut micorbes and metabolites that extend fly lifespan

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K19330
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 47:Pharmaceutical sciences and related fields
• Research Institution: Kanazawa University
• Principal Investigator: Kuraishi Takayuki 金沢大学, 薬学系, 准教授 (90613167)
• Co-Investigator(Kenkyū-buntansha): 栗原 新 近畿大学, 生物理工学部, 准教授 (20630966)
• Project Period (FY): 2021-07-09 – 2023-03-31
• Keywords: 腸内細菌

Outline of Final Research Achievements

We have developed a novel technique that enables one to keep germ-free flies for multiple generations. We found that larvae raised with γ-ray irradiated food stopped their growth, and that adult flies raised with γ-ray irradiated food (larval stage, autoclaved food) reduced their lifespan significantly. In this study, we isolated several gut bacteria from our wild-type flies, and generated gnotobiotic flies with those bacteria. We found that Acetobacter recovered both larval growth and reduced adult lifespan. We also identified a micronutrient that could be supplied by Acetobacter recovered both larval growth and reduced adult lifespan.

Free Research Field

自然免疫学

Academic Significance and Societal Importance of the Research Achievements

高齢化が世界中で進展し、健康寿命を伸ばすための基礎的研究が期待されている。「もう一つの臓器」としての腸内細菌叢は、健康寿命延伸を目的とした介入の対象として、近年特に注目を集めている。腸内細菌が宿主に与える影響の分子基盤として、腸内細菌が産生する代謝産物が重要な要素と考えられている。本研究では、栄養不足の飼育環境において、酢酸菌が産生する微量栄養素がショウジョウバエの成長や寿命をサポートすることを示した。