Search for Molecular Targets in Inflammatory Bowel Disease Drugs

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K19523
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
• Research Institution: Niigata University
• Principal Investigator: Nakatsu Fubito 新潟大学, 医歯学系, 准教授 (50360607)
• Project Period (FY): 2021-07-09 – 2024-03-31
• Keywords: 炎症性腸疾患

Outline of Final Research Achievements

Inflammatory bowel disease (IBD) is an intractable disease characterized by chronic inflammation of the intestinal tract. Its etiology and pathogenesis remain largely unknown. In the current study, we established an evaluation platform for the discovery of molecular target drugs based on the cellular response mechanism recently identified by our group. We have found that our system is a highly sensitive platform to chemicals that perturb cellular function.

Free Research Field

細胞生物学

Academic Significance and Societal Importance of the Research Achievements

炎症性腸疾患は、腸管組織に炎症や潰瘍を引き起こす疾患の総称であり、その病因や詳細な発症メカニズムについては依然不明な点が多い。本研究で構築した評価系は、極めて感受性の高いプラットフォームであることが判明したことから、分子メカニズムの探索や病態解明研究などの基礎研究に大きく貢献する可能性が期待される。さらに、様々な応用研究への展開の可能性も期待されることから、社会的にも意義深いと考えられる。