2023 Fiscal Year Final Research Report

Longitudinal outcomes of children born after labor epidural anesthesia

Research Project

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Project/Area Number	21K19639
Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type	Multi-year Fund
Review Section	Medium-sized Section 58:Society medicine, nursing, and related fields
Research Institution	Hamamatsu University School of Medicine
Principal Investigator	Kenji Tsuchiya 浜松医科大学, 子どものこころの発達研究センター, 特任教授 (20362189)
Co-Investigator(Kenkyū-buntansha)	秋永智永子浜松医科大学, 医学部附属病院, 特任助教 (40402333) 谷口美づき浜松医科大学, 医学部附属病院, 診療助教 (60402319) 成瀬智浜松医科大学, 医学部附属病院, 診療助教 (90647611) 朝羽瞳浜松医科大学, 医学部附属病院, 診療助教 (20869515) 伊東宏晃浜松医科大学, 医学部, 教授 (70263085) 高橋長秀名古屋大学, 医学部附属病院, 准教授 (50846714) Rahman Md.Shafiur 浜松医科大学, 子どものこころの発達研究センター, 特任講師 (60874360)
Project Period (FY)	2021-07-09 – 2024-03-31
Keywords	無痛分娩 / 硬膜外麻酔 / 自閉スペクトラム症 / メタ解析
Outline of Final Research Achievements	A literature review was conducted on the association between epidural anesthesia during childbirth and the risk of autism spectrum disorder (ASD). Specifically, a systematic review and meta-analysis were performed to integrate data from multiple observational studies and evaluate the impact of epidural anesthesia use on the risk of ASD. The findings indicated that the use of epidural anesthesia might significantly increase the risk of ASD. However, the heterogeneity among the studies was high, suggesting that further research is necessary. Notably, these findings could not be replicated in the Hamamatsu Mother and Child Birth Cohort (N=1258) managed by the applicant.
Free Research Field	医学（社会医学）
Academic Significance and Societal Importance of the Research Achievements	硬膜外麻酔がASD発症リスクに与える可能性についての正しい情報を提供し，臨床および政策決定に役立つ可能性がある。社会的意義としては，出産時の麻酔選択に対する理解を深め，母親たちの不安を軽減し，より安全で効果的な出産管理を促進する助けとなる。