• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2022 Fiscal Year Research-status Report

心外膜脂肪の線維化を検出し心房細動ハイリスク患者を同定するCT画像診断法

Research Project

Project/Area Number 21K19658
Research InstitutionOita University

Principal Investigator

高橋 尚彦  大分大学, 医学部, 教授 (30263239)

Project Period (FY) 2021-07-09 – 2024-03-31
Keywords心外膜脂肪
Outline of Annual Research Achievements

We previously investigated the role of EAT in AF in humans. Left atrial (LA) appendage samples were obtained from AF patients during cardiovascular surgery. Histologically, the severity of fibrotic EAT remodeling was associated with LA myocardial fibrosis. Total collagen in the LA myocardium (i.e., LA myocardial fibrosis) was positively correlated with proinflammatory and profibrotic cytokines/chemokines, including interleukin-6, monocyte chemoattractant protein-1, and tumor necrosis factor-α, in EAT. Human peri-LA EAT and abdominal subcutaneous adipose tissue (SAT) were obtained by autopsy. EAT- or SAT-derived conditioned medium was applied to the rat LA epicardial surface using an organo-culture system. EAT-conditioned medium induced atrial fibrosis in organo-cultured rat atrium. The profibrotic effect of EAT was greater than that of SAT. The fibrotic area of the organo-cultured rat atrium treated with EAT from patients with AF was greater than in patients without AF. Treatment with human recombinant angiopoietin-like protein 2 (Angptl2) induced fibrosis in organo-cultured rat atrium, which was suppressed by concomitant treatment with anti-Angptl2 antibody. Finally, we attempted to detect fibrotic EAT remodeling on computed tomography (CT) images, which demonstrated that the percent change in EAT fat attenuation was positively correlated with EAT fibrosis. Based on these findings, we conclude that the percent change in EAT fat attenuation determined using CT non-invasively detects EAT remodeling.

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

「研究実績の概要」に記載したように,おおむね順調に進展している。

Strategy for Future Research Activity

令和5年度は,大動脈弁狭窄症患者に拡げて解析予定である。

  • Research Products

    (2 results)

All 2023

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Role of epicardial adipose tissue in human atrial fibrillation2023

    • Author(s)
      Takahashi Naohiko、Abe Ichitaro、Kira Shintaro、Ishii Yumi
    • Journal Title

      Journal of Arrhythmia

      Volume: 39 Pages: 93~110

    • DOI

      10.1002/joa3.12825

    • Peer Reviewed / Open Access
  • [Presentation] Qualitative alteration of Epicardial adipose tissue and Atrial myocardial fibrosis as a substrate of Atrial fibrillation2023

    • Author(s)
      Takahashi N
    • Organizer
      第86回日本循環器学会学術集会
    • Int'l Joint Research

URL: 

Published: 2023-12-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi