2022 Fiscal Year Final Research Report

Does acute exercise improve hippocampus function in humans?

Research Project

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Project/Area Number	21K19702
Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type	Multi-year Fund
Review Section	Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research Institution	The University of Electro-Communications
Principal Investigator	Ando Soichi 電気通信大学, 大学院情報理工学研究科, 准教授 (50535630)
Co-Investigator(Kenkyū-buntansha)	田代学東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00333477) 藤本敏彦東北大学, 高度教養教育・学生支援機構, 准教授 (00229048)
Project Period (FY)	2021-07-09 – 2023-03-31
Keywords	運動 / 脳 / 海馬
Outline of Final Research Achievements	It is well known that exercise has beneficial effects on human brain function. This is particularly so in the hippocampus function. However, it remains to be established how acute exercise influences dopamine neurotransmission and glucose metabolism in the hippocampus in humans. Therefore, we performed two studies using positron emission tomography. In the first study, we tested if acute exercise releases endogenous dopamine in the hippocampus. In the second study, we investigated whether acute dynamic exercise enhances glucose metabolism in the hippocampus. We observed that acute exercise tended to release endogenous dopamine in the hippocampus. We also observed that acute dynamic exercise did not influence glucose uptake in the hippocampus. The present results provide insight into the effects of acute exercise on dopamine neurotransmission and glucose metabolism in the human hippocampus.
Free Research Field	運動生理学
Academic Significance and Societal Importance of the Research Achievements	運動が脳機能の維持や向上に効果的であることは広く知られている．特に海馬は運動により有益な効果がみられる領域であることが多くの動物実験の結果から示されてきた．しかし，運動により本当に海馬が活性化するのかについて，ヒトを対象として検討した研究は少ない．本研究は，PETを用いてこの疑問を解決しようとする点でオリジナリティが高い研究であるといえる．引き続いて研究を継続し，より精度の高い解析を行うことで，運動と海馬の活性化について新しい知見が得られることが期待される．