Fabrication of granules bond type carbonate apatite artificial bone

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K19914
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 90:Biomedical engineering and related fields
• Research Institution: Kyushu University
• Principal Investigator: Ishikawa Kunio 九州大学, 歯学研究院, 教授 (90202952)
• Project Period (FY): 2021-07-09 – 2024-03-31
• Keywords: 炭酸アパタイト / 人工骨 / 多孔体 / 連通気孔 / 骨梁 / マイクロ構造

Outline of Final Research Achievements

The objective of this investigation is to fabricate porous carbonate apatite artificial bone using not acrylate but cellulose as a binder since cellulose binder allows porous body. It was found that calcium carbonate with cellulose binder also allows the fabrication of porous carbonate apatite artificial bone. When the bone defect of rabbit tibia was reconstructed with the porous carbonate apatite artificial bone, new bone was formed even at the center of the block 4 weeks after surgery. Also, osteoclasts and osteoblasts were found indicating bone remodeling process. Faster replacement to bone was confirmed for cellulose binder used carbonate apatite when compare with that fabricated using acrylate bine. It was, therefore, concluded that not only macro porous structure but also micro structure plays important roles for the replacement of carbonate apatite artificial bone to bone based on bone remodeling.

Free Research Field

生体材料学

Academic Significance and Societal Importance of the Research Achievements

超高齢社会を迎え、骨再建術が急増している。自家骨移植（患者自身の骨を採取して骨欠損治療を行う手法）には健全部位への侵襲という重篤な問題があり、自家骨に匹敵する機能を備える人工骨が望まれている。本研究で開発した連通多孔性炭酸アパタイト人工骨は埋植４週目で中央部まで骨形成され、さらに骨リモデリングによって新しい骨に置換される理想的な人工骨となる可能性が高い。また、マクロ気孔構造だけでなく骨梁部のマイクロ構造が骨置換に影響を及ぼすことが明らかになった。本研究成果を基盤とした高機能性炭酸アパタイト骨補填材の開発が期待される。