2023 Fiscal Year Final Research Report
Development of biodegradable spray using liquefied gases for biomedical application
| Project/Area Number |
21K19928
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 90:Biomedical engineering and related fields
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| Research Institution | Tokai University |
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Principal Investigator |
Okamura Yosuke 東海大学, マイクロ・ナノ研究開発センター, 教授 (40365408)
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| Co-Investigator(Kenkyū-buntansha) |
畑中 朋美 城西大学, 薬学部, 教授 (10198749)
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| Project Period (FY) |
2021-07-09 – 2024-03-31
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| Keywords | 生分解性高分子 / 液化ガス / 紫外線吸収剤 |
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| Outline of Final Research Achievements |
In general, biodegradable polymers exhibit thermoplasticity and are melt-processed into products such as films and fibers. They are also soluble in versatile organic solvents. In this study, we found that liquefied gas can be a new solvent for biodegradable polymers, resulting in the biodegradable spray to provide thin-films on target surfaces. For biomedical application, we demonstrated that the biodegradable thin-film spray containing UV absorbers can act as a UV care material against xeroderma pigmentosum etc.
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| Free Research Field |
生体材料学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果において、液化ガスが生分解性高分子の新しい溶媒になることを見出した点は学術的意義が大きいと考えられる。また、本手法は従来の溶融工程や一般有機溶媒を使用せず、液化ガスを瞬時に気化させて大面積に薄膜化する技術である。あらかじめ成型加工した材料ではないため、標的部位の形状問わず薄膜を貼り付けることができる点も学術的意義は大きい。また、本成果は、医療用途に限らず環境配慮型材料への応用も期待できる。
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