Suppression of brain inflammation through induction of endogenous anti-inflammatory compound by prebiotics and probiotics

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K20573
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0601:Agricultural chemistry and related fields
• Research Institution: Shibata Gakuen University
• Principal Investigator: Okuno Alato 柴田学園大学, 生活創生学部, 准教授 (50623980)
• Project Period (FY): 2021-08-30 – 2023-03-31
• Keywords: キヌレニン / トリプトファン代謝 / プレバイオティクス

Outline of Final Research Achievements

Specific heat killed lactic acid bacteria (HK-LAB) tended to decrease inflammatory cytokine IL-1β in brain inflammation model mice. This indicates that ingestion of HK-LAB may also suppress inflammation caused by strong inflammatory agents such as LPS.
In addition, it was clarified that administration of killed lactic acid bacteria to dysbiosis model mice by administration of antibiotics markedly increased in KYN levels in blood. It was suggest that administration of HK-LAB may promote inflammatory reactions caused by dysbiosis. It is necessary to investigate how HK-LAB intake affects kynurenine metabolism and the effects of fluctuating kynurenine on the body in the future.

Free Research Field

栄養学

Academic Significance and Societal Importance of the Research Achievements

乳酸菌の摂取が炎症抑制物質キヌレニンレベルを上昇させ、全身の炎症を抑制する可能性を示した。この結果は加熱して死菌化した菌体によるものであり、摂取する菌は必ずしも生きている必要が無い。これらのことは種々の食品に乳酸菌死菌体を加えることで味を含む食品の品質を変化させることなく、背景に炎症が関係している様々な疾患が予防可能であることを示している。また本研究で調べたトリプトファンーキヌレニン代謝を指標としてさらに多くの菌株の有用性を調べることで比較的容易に抗炎症性作用を有する菌株を探索することができるかもしれない。