2022 Fiscal Year Final Research Report
The Mechanisms of Skeletal Muscle Regulation by SIRT1 and Its Age-Related Changes, Gender Differences
| Project/Area Number |
21K20892
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0902:General internal medicine and related fields
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Hosoi Tatsuya 東京大学, 医学部附属病院, 助教 (70907831)
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| Project Period (FY) |
2021-08-30 – 2023-03-31
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| Keywords | サルコペニア / 長寿遺伝子 / Sirt1 |
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| Outline of Final Research Achievements |
Using Cre-loxP systems, we generated a new mouse model (fmSirt1KO mice) in which the Sirt1 function was selectively deleted in the fast-twitch muscle fibers. In this model, we analyzed the body weight and muscle mass, as well as muscle function and metabolic changes. In young mice, there was no difference in muscle mass or function. However, metabolic changes, including changes in dark-phase oxygen consumption, were suggested with aging.
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| Free Research Field |
老年医学
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| Academic Significance and Societal Importance of the Research Achievements |
骨格筋におけるSirt1作用はミトコンドリア代謝などを介し, 筋質に影響をおよぼす一方, 筋重量維持には大きく影響しない可能性が示唆された. またSirt1機能は年齢依存的に変化する可能性が考えられた. 今後Sirt1アゴニストによる機能回復などを検討することで, 社会的課題であるサルコペニアの治療や予防の一助となる可能性が期待される.
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