Penumbra Detection With Oxygen Extraction Fraction Using Magnetic Susceptibility in Patients With Acute Ischemic Stroke

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K20908
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0902:General internal medicine and related fields
• Research Institution: Nagoya City University
• Principal Investigator: KANO YUYA 名古屋市立大学, 医薬学総合研究院(医学), 研究員 (80913293)
• Project Period (FY): 2021-08-30 – 2024-03-31
• Keywords: ペナンブライメージ / 定量的磁化率画像 / 急性期脳梗塞 / MRI

Outline of Final Research Achievements

We consecutively studied 21 patients (12 men, 9 women, mean age ± SD: 76.1 ± 7.4 years) who were admitted within 24 hours of stroke onset with major artery occlusion in the anterior circulation. We compared the ischemic penumbra volume, determined using the conventional DWI-PWI mismatch method, with the volume of regions with increased OEF obtained from our developed PRESTO-QSM. A correlation was observed between the two, suggesting that PRESTO-QSM has potential as a penumbra biomarker to guide treatment selection in acute cerebral infarction.

Free Research Field

神経内科学

Academic Significance and Societal Importance of the Research Achievements

本研究ではQSMで得られた低灌流領域を用いて，造影剤を使用しなくても脳組織の低灌流領域を描出できる次世代MRI画像バイオマーカーを確立させることができた．造影剤を使用せずに非侵襲的に実施できるようになれば，ペナンブラ領域の評価をより多くの施設で行えるようになると考えている．ペナンブラ領域を評価することで，再灌流療法の適応の判断が定量的に行えるようになり，多くの症例が安全で有効な治療を受けられる機会が増えると期待できる．