Development of a disease-specific scale for quality of life and treatment effect of adult spinal deformities

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K20966
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0906:Surgery related to the biological and sensory functions and related fields
• Research Institution: Osaka University
• Principal Investigator: Fujimori Takahito 大阪大学, 大学院医学系研究科, 講師 (80546888)
• Project Period (FY): 2021-08-30 – 2024-03-31
• Keywords: 成人脊柱変形 / 疾患特異尺度 / 健康関連QOL / 患者報告型アウトカム評価 / 患者満足度 / 脊椎手術 / 因子分析

Outline of Final Research Achievements

Adult spinal deformity (ASD) is a complex condition. The lack of a scale that can successfully capture this complex condition is a clinical challenge. We aimed to develop a disease-specific scale for ASD. The study included 106 patients with ASD. We selected 29 questions that could be useful in assessing ASD. The factor analysis found two factors: the main symptom and the collateral symptom. The main symptom assessed activity of daily living (ADL), pain, and appearance. The collateral symptom assessed ADL due to range of motion limitation. The effect size of Cohen’s d for comparison between preoperative and postoperative scores was 1.09 in the main symptom and 0.65 in the collateral symptom. We have developed a validated disease-specific scale for ASD that can simultaneously evaluate the benefits and limitations of ASD surgery with enough responsiveness in clinical practice.

Free Research Field

整形外科学

Academic Significance and Societal Importance of the Research Achievements

近年増加している成人脊柱変形における疾患特異尺度を開発することで、成人脊柱変形における病態、治療意義などをより正確にとらえることができることになった。新しい視点からの尺度の開発は、患者の日常生活における障害や生活の質への影響をより正確に評価し、手術や保存的治療の成果を測定するための基準を提供できる。これにより、臨床医は患者の症状や生活の質に基づいたより適切な治療選択が可能となり、患者中心のケアが実現できる。また、この研究成果は医療政策や資源配分においても重要な指標となり得るため、学術的及び社会的に大きな意義を持つと考えられる。