Elucidating the Mechanism of Renoprotective Effect of Oral Si Agent Inducing Intrinsic Hydrogen Generation

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K20970
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0906:Surgery related to the biological and sensory functions and related fields
• Research Institution: Osaka University
• Principal Investigator: TANAKA RYO 大阪大学, 医学部附属病院, 医員 (60909654)
• Project Period (FY): 2021-08-30 – 2023-03-31
• Keywords: 腎線維化 / 酸化ストレス / 腎不全 / シリコン / マウス

Outline of Final Research Achievements

A common pathology in the progression from chronic kidney disease to end-stage renal failure is the development of fibrosis in the renal tubular interstitium. This fibrosis is known to be accelerated by oxidative stress caused by hydroxyl radicals and other cytotoxic reactive oxygen species. Our research focused on the potential of hydrogen to reduce oxidative stress, and we have established a novel method of hydrogen administration through oral Si agent. Our findings demonstrate that the administration of Si agent effectively suppresses renal fibrosis by reducing local oxidative stress within the kidneys, inhibiting cell death in renal tubular cells, and suppressing the expression of factors that promote fibrosis.

Free Research Field

腎移植

Academic Significance and Societal Importance of the Research Achievements

シリコン製剤の経口摂取は、腸管内で多量の水素を発生させることができ、簡便で安全な画期的治療方法としての臨床応用が高く期待され、高い独自性と創造性を有する。また、腎線維化抑制を通じて慢性腎臓病の進行を抑えることができれば、臨床上極めて有効性が高い治療法となる可能性がある。