2022 Fiscal Year Final Research Report
the development of bioactive titanium membrane
| Project/Area Number |
21K21088
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
0907:Oral science and related fields
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2021-08-30 – 2023-03-31
|
| Keywords | 骨再生 / 歯科用インプラント / GBR |
|---|
| Outline of Final Research Achievements |
The low-crystallinity Ca-P membrane was found to release Ca ions in a low-Ca environment and to act as a Ca reservoir in a high-Ca environment, and to be as effective as bioactive membranes in cell proliferation. In addition, the study of the bone regeneration using SD rats showed no significant difference in the amount of bone regeneration between control membrane and low-crystallinity Ca-P membrane. The number of osteogenesis in the center of bone defects was higher than that of control membranes. Low-crystalline Ca-P may have an advantage in that it is rapidly leached into serum under low-Ca conditions, but in healthy animal models, it may act as a Ca reservoir and no significant differences were observed in this study.
|
| Free Research Field |
歯科補綴学
|
| Academic Significance and Societal Importance of the Research Achievements |
低結晶性Ca-Pメンブレンが低Ca環境下においてはCaイオンを徐放し，高Ca環境下ではCaのリザーバーとなること，また骨芽細胞様細胞の細胞増殖を阻害しないことを明らかにした．健常モデルにおいては骨再生への優位性は認めなかったが，低Ca環境下においては，治癒初期の一時的Ca濃度の上昇により骨形成能が改善される見込みがあると考える。従って，低Ca状態や骨密度が低下した状況に用いる生体材料としての可能性があると考えられる．
|
