Elucidation of new functions of GPRC5B, a poor prognostic factor mediated by cancer-specific caveola

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K21101
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Kanagawa Dental College
• Principal Investigator: Kanamori Keisuke 神奈川歯科大学, 歯学部, 助教 (70911296)
• Project Period (FY): 2021-08-30 – 2023-03-31
• Keywords: GPRC5B / 頭頸部扁平上皮癌 / 癌糖代謝 / 口腔癌

Outline of Final Research Achievements

Comparison of GPRC5B expression levels and 5-year survival rates in each cancer carrier using an open database suggests that GPRC5B may act as a prognostic factor in many cancer types. Molecular biology studies using head and neck squamous cell carcinoma cell lines suggest that GPRC5B is involved in avoidance of glucose starvation-induced apoptosis in head and neck squamous cell cell lines.

Free Research Field

口腔癌、頭頸部癌

Academic Significance and Societal Importance of the Research Achievements

診断時にGPRC5Bの発現レベルを検討することで、ケトン食療法の治療前効果判定のマーカーとして応用できる可能性がある。GPRC5Bは受容体であるため、結合するリガンドを同定することで将来的に分子標的治療薬(抗体薬)としての応用も十分可能であると考える。